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Wound healing Models

We are licensed to undertake studies in a range of experimental model systems that are widely used in wound healing research.

 

The majority of our pre-clinical work centres around the investigation of “agents” in terms of their impact on the repair of incisional & excisional surgical wounds under both ‘normal’, compromised (diabetes-impaired) and infected conditions.

 

Using these models we are able to examine the ability of agents to modulate (improve or impair) the wound healing process and also investigate the physical performance of wound management devices (exudate management, wound site adherence, tissue viability).

Normal Wounds

  • Incisional or excisional

  • Partial or full thickness

  • Application/re-application of agents/devices under test

  • Calibrated digital photography for wound closure planimetry

  • Performance assessment:- exudate management, wound site adherence/ ease  of removal, dressing integrity, dressing debris deposition

  • Histological and biochemical assessment

  • Up to 12 month study

  • Detailed data analysis, statistical testing, digital imagery & report provision.

Diabetes-impaired Wounds

Infected Wound Models

  • Full thickness excisional wounds

  • Mono-microbial (S.aureus/P.aeruginosa) inoculation

  • Establishment of infection based on CFU count and clinical signs

  • Application/re-application of agents/devices under test or controls

  • Calibrated digital photography for wound closure planimetry

  • Assessment of infection level and wound closure over time

  • Determination of Log kill

  • Histological and biochemical assessment of wound

Assessments

The impact of investigational agents / therapies on wound healing can be assessed using a variety of measurement parameters and endpoints.

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