The impact of agents on wound closure is assessed using excisional wound models.
Wound closure, which is measured by computer-assisted planimetry from calibrated
images taken at intervals during the study, can be differentiated into its components:-
Wound Re-epithelialisation & Wound Contraction (see below)
Original wound area
Area closed by contraction
Area closed by re-epithelialisation
Open wound area remaining
Data showing % wound area remaining (relative to the original wound area on day 0)
± s.e.m. for a diabetes-impaired wound healing model .
The components of wound closure (% wound re-epithelialisation and % wound contraction)
are also displayed, demonstrating a reduced ability of wound closure by contraction
in diabetes-impaired wounds accompanied by a slight increase in wound closure by
Treatment with a growth factor combination therapy (positive control) demonstrates
a positive modulation of both components .
Diagram showing wound planimetry measurements in a normal wound healing model.